4-Chlorobenzhydryl Piperazine

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2,100.00 - 2,500.00 / Kilogram( + 18% GST applicable)

25 Kilogram (MOQ)

Business Type Manufacturer, Supplier
Application Intermediate Of Cetirizine /Levo Cetrazine
CAS No. 303-26-4
Purity ≥ 99%
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Product Details

Sealing Type
Double Seal
Country of Origin
India
Molecular Formula
C17H19ClN2
Molecular Weight
286.80 G/mol
CAS Number
303-26-4
Melting Point
105 - 110 °C
Boiling Point
~420 °C (at 760 MmHg, Decomposes)
Also Known As
P-chloro Benzhyryl Piperazine, PCBHP
Product Code
CAS no 303-26-4
Port
All over india
Delivery Time
Ready stock
Packaging Details
The primary application of 4-chlorobenzhydryl piperazine (Norchlorcyclizine, CAS 303-26-4) is as a key pharmaceutical intermediate for synthesizing several important drugs. It is not typically used as an active ingredient itself but as a crucial building block in manufacturing other complex molecules.
Key applications include:
Synthesis of Antihistamines: It is a primary precursor for a range of well-known antihistamine medications. These include:
Cetirizine (e.g., Zyrtec)
Hydroxyzine (used for allergies and anxiety)
Meclizine (used for motion sickness and vertigo)
Chlorcyclizine
Research and Development: It is widely used in chemical and neuroscience research to explore new molecular designs and potential drug candidates. This includes studies in:
Developing novel anticancer agents and investigating their cytotoxicity.
Identifying potential inhibitors for specific biological targets, such as voltage-gated sodium channels (Nav1.7).
Synthesizing potential antipsychotic and antidepressant agents.
Analytical Standards: It is used as a reference standard in analytical chemistry, particularly for identifying and quantifying impurities in commercial preparations of hydroxyzine and cetirizine, as it is an inactive metabolite of these drugs.
The primary application of 4-chlorobenzhydryl piperazine (Norchlorcyclizine, CAS 303-26-4) is as a key pharmaceutical intermediate for synthesizing several important drugs. It is not typically used as an active ingredient itself but as a crucial building block in manufacturing other complex molecules. 
Key applications include:
  • Synthesis of Antihistamines: It is a primary precursor for a range of well-known antihistamine medications. These include:
    • Cetirizine (e.g., Zyrtec)
    • Hydroxyzine (used for allergies and anxiety)
    • Meclizine (used for motion sickness and vertigo)
    • Chlorcyclizine
  • Research and Development: It is widely used in chemical and neuroscience research to explore new molecular designs and potential drug candidates. This includes studies in:
    • Developing novel anticancer agents and investigating their cytotoxicity.
    • Identifying potential inhibitors for specific biological targets, such as voltage-gated sodium channels (Nav1.7).
    • Synthesizing potential antipsychotic and antidepressant agents.
  • Analytical Standards: It is used as a reference standard in analytical chemistry, particularly for identifying and quantifying impurities in commercial preparations of hydroxyzine and cetirizine, as it is an inactive metabolite of these drugs. 

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